Department: Basic Sciences
Laboratory: Biology - Biochemistry lab
Director: Associate Professor Antonios Stamatakis, PhD
Laboratory Contact Details
Room / Building
- Room 2.19/2.20
Central building of the Department of Nursing
Papadiamantopoulou 123, 11527 Athens, Greece
General Description
The Biology-Biochemistry lab studies the biological base of behaviour using animal models. More specifically, we investigate the cellular and biochemical effects of early life experiences on the brain of rodents as well as the neurohormonal aspects of maternal behaviour.
Laboratory Staff
- Stamatakis Antonios, Associate Professor, astam[at]nurs[dot]uoa[dot]gr
- Panagiotidou Emily, PhD candidate, emily-panagiotidou[at]hotmail[dot]com
- Ferle Vassiliki, PhD candidate, vferle[at]yahoo[dot]com
- Papadopoulou Anastasia-Konstantina, MSc graduate student, nanpap95[at]gmail[dot]com
- Prosilis Antonis, MSc graduate student, prosilis[at]uth[dot]gr
- Nikolaou Eleni, Undergraduate student, elenniko6[at]mbg[dot]duth[dot]gr
- Trichas Panagiotis, Undergraduate student, panosu[at]hotmail[dot]com
Laboratory Courses (undergraduate and postgraduate curriculum) - taught in the laboratory
Undergraduate Program
Postgraduate Program
Infrastructure
- System for the documentation and analysis of animal behaviour-Noldus
- Behavioral apparatuses: Morris Water Maze, Startle Response/Reflex System, Fear conditioning, Elevated plus maze, Open field, T-maze, Y-maze
- Image analysis system connected to a microscope
- HPLC system
- PCR
- DNA and protein electrophoresis system
- DNA documentation system
- Cryostat
- Paraffin microtome
- System for the production of pure water
- Cooled centrifuge
- Incubation chamber
- Deep freezer
Laboratory Research Activities
- Effects of an adverse early life experience on prefrontal cortex structure and function in rodents.
- Effects of mixtures of endocrine distruptors on mouse brain and behaviour- EDC-MixRisk, European Commission DIRECTORATE-GENERAL FOR RESEARCH & INNOVATION – ΗΟΡΙΖΟΝ 2020
- Phenotyping and archiving of model mammalian genomes - InfrafrontierGR/ Phenotypos, Ministry of Education, Research and Religious Affairs
Publications
- Segklia K*, Stamatakis A*, Stylianopoulou F, Lavdas A.A., Matsas R. “Increased Anxiety-Related Behavior, Impaired Cognitive Function and Cellular Alterations in the Brain of Cend1-deficient Mice.” Frontiers Cellular Neuroscience, 12:497, 2019. doi: 10.3389/fncel.2018.00497. * Συγγραφείς με ισότιμη συνεισφορά
- Diamantopoulou A., Kalpachidou T., Aspiotis G., Gampierakis I., Stylianopoulou F*, Stamatakis A.* “An early experience of mild adversity involving temporary denial of maternal contact affects the serotonergic system of adult male rats and leads to a depressive-like phenotype and inability to adapt to a chronic social stress.” Physiol Behav. 184:46-54. doi: 10.1016/j.physbeh.2017.11.004, 2018. * Συγγραφείς με ισότιμη συνεισφορά
- Manatos V., Stylianopoulou F., Stamatakis A. “The levels of the GluN2A NMDA receptor subunit are modified in both the neonatal and adult rat brain by an early experience involving denial of maternal contact.” Neurosci. Lett. 612:98-103. doi: 10.1016/j.neulet.2015.12.005.
- Stamatakis A., Manatos V., Kalpachidou T., Stylianopoulou F. “Exposure to a mildly aversive early life experience leads to prefrontal cortex deficits in the rat”, Brain Structure and Function, 221(8):4141-415, DOI: 10.1007/s00429-015-1154-0, 2016.
- Kalpachidou T, Raftogianni A, Melissa P, Kollia AM, Stylianopoulou F, Stamatakis A. “Effects of a Neonatal Experience Involving Reward Through Maternal Contact on the Noradrenergic System of the Rat Prefrontal Cortex.” Cereb Cortex. 26(9):3866-77. doi: 10.1093/cercor/bhv192, 2016.